SimulSorbSM/SimulOxSM Pseudo-Empirical Modeling for:

HFA Aerosol Metered Dose Inhalers and their Packaging

  • Pharmaceutical Industry no longer exempt from Montreal Accord governing the use of CFCs
  • Propellant replacement is very hygroscopic hydrofluoroalkane (HFA)
  • HFA will adsorb moisture into dosing chamber resulting in physical and/or chemical degradation of the drug product and corrosion of mechanical parts resulting in dosage control problems
  • Problems are easily remedied with the use of drop-in; fit-in; or built-in sorbents

Dry Powder Inhalers and their Packaging (Reservoir & Pre-Measured Dose)

  • As in the case with all solid-state formulations, increased moisture can increase the rate of degradation in DPI formulations
  • Many DPI formulations will agglomerate in the presence of moisture resulting in dosage control problems
  • Moisture source is ingress and from plastic materials used in DPI device construction
  • Multisorb provides sorbent application technology consultation for its products to pharmaceutical companies during the formulation, filling, containment and aerosolization development efforts for DPI platforms
  • Reduce potential or better manage triboelectrification, whereby an electrostatic charge is generated by the contact and separation of two dissimilar materials, resulting in oppositely charged surfaces and related dosing problems
  • Prevention of drug product formulation particle agglomeration and related dosing problems (deagglomeration)
  • Agglomeration prevention while managing electrostatic potential can be balanced with conditioned drop-in; fit-in; or built-in conditioned sorbents or specialized moisture-management systems